Endocrine Abstracts

BackgroundFluid balance in patients with diabetes insipidus and COVID-19 is very fragile. The prevalence of hyponatraemia in patients with pneumonia due to COVID-19 seems to be low, but in patients admitted to intensive care units (ICU) is high (up to 20.5%). In contrast, hypernatraemia may also develop in COVID-19 patients in ICU (up to 3.7% of cases), due to insensible water losses from pyrexia, increased respiration rate and use of diuretics. Both hyp...

Introduction: Ipilimumab is an efficient medication used for the management of melanoma. However, it has been associated with endocrine dysfunctions such as hypophysitis, thyroid disorders (hypo- or hyperthyroidism), and adrenal insufficiency.Case report: We report the case of a 65-year-old male diagnosed with melanoma (Clark V). In 2022, he was operated and received treatment with ipilimumab 3 mg/kg. Three weeks after t...

Background: September is celebrated as PCOS awareness month worldwide and is aimed at improving the lives of those with PCOS, promoting research, and strengthening advocacy efforts. While significant financial and human resources are invested in promotions during this month, to the best of our knowledge, there is no evidence to show the impact of this initiative. In our study, we evaluated the global digital impact of PCOS Awareness Month, tracking commonly used hashtags as su...

Introduction: The global migration of healthcare professionals has enabled those trained in low-and-middle income countries (LMICs) to move and work in high-income countries (HICs) and vice-versa. While medical licensing exams in HICs are designed to assess competency of the immigrating HCPs, there is limited literature on the differences in approach to manage clinical cases between those from LMIC and HIC. Simulation via Instant Messaging – Birmingham Advance (SIMBA) is ...

Background and Aim: Unacylated ghrelin (UAG) is the major form of circulating ghrelin. Initially considered as a non-functional peptide, soon after UAG has been associated to a negative action on energy balance, suppression of hepatic glucose production and decrease in circulating levels of insulin. The aim of this study was to analyze the association between the serum levels of UAG and glucose metabolism parameters in obese women, independently from the eventual interference ...

Purpose: The hormonal thyroid changes related to obesity, even when in the euthyroid state, may contribute to the unfavorable cardio-metabolic profile of obese patients. In this retrospective study we aim to investigate the biochemical thyroid changes and the association between serum TSH, FT4, FT3 and cardio-metabolic risk factors in euthyroid obese youths.Methods: Four hundred ninety-one Caucasian euthyroid obese children and adolescents aged 9.93±2...

Background: The typical biochemical phenotype related to obesity, that is high serum TSH within normal range, low/normal free thyroxine (FT4) and increased free triiodothyronine (FT3) levels, can be interpreted as a resistance to thyroid hormones. It is unclear the role played by thyroid hormones in the pathogenesis of metabolic derangement associated with obesity. Aim: To investigate the association between thyroid hormones sensitivity and cardio-metabo...

Introduction: X-linked adrenoleukodystrophy (X-ALD) is a rare condition presented mainly in males during childhood and early adulthood. It represents almost 10% of primary adrenal insufficiency (PAI) or Addison’s disease cases.Clinical case: A 67-year-old male was diagnosed at the age of 61 with PAI during testing for mesenteric paniculitis while admitted in Internal Medicine service. He was treated with hydrocortisone and referred to outpatient end...

Introduction: Catecholamine-secreting tumours derived from the adrenal medulla and the nodes of the autonomic nervous system are known as pheochromocytomas or paragangliomas, respectively. Although their clinical manifestations are similar, their differentiation is important from an epidemiological and prognostic point of view and their possibility of being associated with genetic syndromes.Case report: We present a case of a 16 year old patient, with no...

Introduction: Cardiovascular disease is present in up to 60% of patients diagnosed of acromegaly and is responsible of the major related morbidity and mortality.Case report: A 79-year-old-woman with previous history of diabetes mellitus and hypertension was admitted for acute pulmonary edema. Transthoracic echocardiogram showed a severe left ventricular dysfunction with an ejection fraction of 20%, dilated left ventricle and left atrium with a moderate m...